Led by the University of Southern California Information Sciences Institute (USC/ISI), the Defense Ready Electronics and Microdevices Superhub (DREAMS) is one of eight regional innovation hubs established under the Department of Defense Microelectronics Commons Program. This strategic initiative is funded by the CHIPS and Sciences Act of 2022 to develop onshore microelectronics hardware prototyping. DREAMS unites academic and commercial organizations across Southern California and our partners across the United States with three goals: maturation of advanced RF technologies for rapid prototyping, lab-to-fab transition of semiconductor technologies and training the next-generation of engineers in advanced RF and microelectronics technologies. The pioneering USC/ISI MOSIS Multi Project Wafer (MPW) fabrication services is at the core of DREAMS. MOSIS is a transformative service that has streamlined the end-to-end prototyping of microchips for educational, commercial and national security applications for over 40 years. MOSIS 2.0 connects customers to an extensive network of state-of-the-art nanofab and foundry services, accelerating the use of advanced process and prototyping technologies within the DREAMS hub, and reducing barriers to innovation.